Methotrexate and mucositis: A merry-go-round for oncologists

Methotrexate and mucositis: A merry-go-round for oncologists

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High-dose methotrexate is the backbone of various regimens for treating lymphoid malignancies.Mucositis is a well-known, dose-related side effect of methotrexate.Prophylactic measures such as folinic acid rescue are useful but steely dan gaucho t-shirt do not prevent mucositis in all the cases.Once severe mucositis whip carbon magnum (WHO Grade IV) sets in, mortality is very high.The index case highlights the natural course of methotrexate-induced mucositis and the need for swift and preemptive intervention.